Psoriasis Genetics Laboratory
Department of Dermatology
University of Michigan
About the study

Psoriasis is an inflammatory skin disorder that affects approximately 2% of Americans
(click here to see examples of psoriasis). Because only about one-third of all patients with
psoriasis have a relative who is also affected with the disorder, psoriasis is not widely
recognized as a genetic disease. However, previous research on families and identical
twins has shown psoriasis has a strong genetic component, although environmental
factors (such as infections, stress, and injuries) are also important. The reason that
psoriasis is not widely recognized as a genetic disorder is because more than one gene is
probably required to develop disease. The purpose of this study is to identify these genes.

Our study was started in 1991 with a goal to identify the genetic bases of psoriasis. Since
then work from our laboratory as well as others have revealed that psoriasis is a
"complex disease" which may involve genetic, immunological and environmental factors.
Our focus is on the genetic aspects of psoriasis. Research during the last ten years has
revealed over forty potential gene locations that may contribute to psoriasis, some more
important than others. No definite psoriasis gene has yet been identified. Once the
general gene locations are identified, the next step is to test genes and gene regulating
regions of DNA that may be involved by an analysis method called genetic association
testing. Since this is a statistical analysis, obtaining reliable results requires testing a
large number of patients. We estimate that it will take approximately 5,000 participants
affected with psoriasis and an equal number of unaffected controls to get reliable results.
If you are interested in participating in the study, click here for details of study criteria.
Additional information is also detailed in the Consent to be Part of a Research Study
document.We believe that this research will provide information about the fundamental
cause of psoriasis, which will greatly help in the design of better treatments for this

This study has been reviewed and approved by the Institutional Review Board for human
subject research at the University of Michigan (IRBMED No. HUM00037994) and adheres
to all applicable regulations.